Aids Vaccine 1

Currently, there is not a vaccinum for the AIDS virus, nevertheless things have been progressing toward an effective one for many age. An AIDS vaccine can be effective in two slipway. Hopefully we can come up with a vaccine to prevent or stay illness in those already infected. A preventative vaccine is a substance introduced into the human consistence that teaches the immune system to detect and destroy a pathogen. Another way would be through a therapeutic vaccine to prevent or delay illness in those already infected. The basic idea behind all AIDS vaccines is to encourage the human immune system to fight the virus.Early vaccine look for focused on teaching the immune system to produce antibodies that would block the virus from entering human cells. However, products designed to work this way failed in clinical trials because the antibodies worked only against lab-cultured human immunodeficiency virus, not against the strains of the virus. Research has plant that a small num ber of HIV infected people produce broadly neutralizing antibodies to HIV. Those antibodies neutralize a blue percentage of the several(predicate) types of HIV. These antibodies are now the basis for new look into into vaccine development.There are several reasons that developing a vaccine is a onerous challenge for scientists. Currently no one has yet to recover from an HIV infection, so there is not a natural mechanism to imitate in a vaccine. Soon after being infected, HIV inserts its genetic material into human cells, where it corpse hidden from the immune system. HIV also occurs in different forms and is constantly changing, meaning that HIV is highly variable. Another reason is that there arent any good animal models to use in experiments for testing, except for the new research conducted by scientists located in Oregon.There have been recent developments from scientists at Oregon Health Science University in developing an AIDS vaccine in rhesus monkey monkeys. The scient ists discuss cytomegalovirus, or CMV, which they claim most people become infected with during their childhoods. This virus persists in its human hosts for life without causing harm and they theorize that it may be an answer to help find a vaccine for the AIDS virus. Using CMV as a vehicle may overcome the hurdle in discovering a vaccine for the virus.In the study, vaccinated monkeys kept a protective force of killer T-cells in circulation. Because CMV persists and constantly stimulates the immune system, it maintains combat readiness, claims Louis Picker, a scientist at OSHUs Vaccine and Gene Therapy Institute and Oregon National Primate Research Center in Hillsboro, Oregon. (Rojas-Burke). The basic idea of using CMV is that it remains in our system for life, which means that it could be used as a vaccine carrier and produce lifelong immunity to the AIDS virus. It keeps large come of immune system soldiers out at the frontlines all the time, basically for life, waiting for that pathogen invasion, and it catches HIV early when its still weak, says Picker. He is still looking at ways to alter the virus to limit its ability to replicate in people, which he figures will take three years of work to make a vaccine candidate ready for human clinical trials. (Rojas-Burke). There is still hope though in finding a vaccine for the virus, since we know that it took many years to develop one for other diseases, such as polio.People remain healthy for several years after becoming infected with HIV. In addition, neutralizing antibodies that have been found among a minority of people suggest that the immune system can be effective in controlling HIV. Aderem, A. (2011). Fast Track to Vaccines. Scientific American, 304(5), 66-71. Retrieved from EBSCOhost Munier, C. , Andersen, C. R. , & Kelleher, A. D. (2011). HIV Vaccines Progress to Date. Drugs, 71(4), 387-414. Retrieved from EBSCOhost Rojas-Burke, Joe. An AIDS Vaccine Developed by Oregon Scientists Stops Infections in a n Animal Model. The Oregonian 11 May 2011. Web. 16 Aug. 2011.